Why did they expect Astronaut Scott Kelley's telomere shortening to accelerate? (they got longer!) ...
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Why did they expect Astronaut Scott Kelley's telomere shortening to accelerate? (they got longer!)
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Planned maintenance scheduled April 17/18, 2019 at 00:00UTC (8:00pm US/Eastern)Is telomere length a reliable measure of health/lifespan?Why are women more susceptible to radiation?Telomere elongation methods?Is telomere shortening consistant over consecutive cell divisions from zygote to a differentiated cell?Telomere shortening during replicationHow much does the Hayflick limit/telomere length vary across taxa and within humans?How do mosquitoes maintain telomere length?How does the telomere repeat sequence vary in Eukaryotes?Can telomere length maintenance be an answer to increased life span of human beings?Why telomere shortening slowing down cancer?
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The NPR News article and podcast Scientists Share Results From NASA's Twins Study says:
SCOTT KELLY (NASA Astronaut): You know, the symptomatic stuff is fine. I don't have any long-term negative feelings, physically, from being in space. Now, there's the things you can't feel. And hopefully, I will never learn that those are a problem.
GREENE (Host): Those things you can't feel - well, it turns out they are as small as the protective structures at the ends of his chromosomes.
MARTIN (Host): Yeah. These are called telomeres, and normally, they get shorter with age. But what about in space?
SUSAN BAILEY (Principle Investigator): What we wanted to do was evaluate telomere length in both of the twins before and after so that we could see, you know, where they started and then where they ended.
MARTIN: Susan Bailey was one of the scientists who answered this question. She expected the stresses of space to shorten telomeres quicker.
BAILEY: And, in fact, we saw exactly the opposite thing - that during spaceflight, he had many more long telomeres than he did before he went up. So that really couldn't have been more of a surprise to us.
See also Radiation Biologist Dr. Susan Bailey Studies the Cellular Clocks of Astronaut Twins
Question: Why did investigators initially believe that Scott Kelley's year in space would accelerate the rate of telomere loss, relative to his baseline rate and the rate of his identical twin brother on the ground? What would be the postulated mechanisms?
molecular-biology radiation telomere
asked yesterday
uhohuhoh
1,6561339
$endgroup$
add a comment |
$begingroup$
The NPR News article and podcast Scientists Share Results From NASA's Twins Study says:
SCOTT KELLY (NASA Astronaut): You know, the symptomatic stuff is fine. I don't have any long-term negative feelings, physically, from being in space. Now, there's the things you can't feel. And hopefully, I will never learn that those are a problem.
GREENE (Host): Those things you can't feel - well, it turns out they are as small as the protective structures at the ends of his chromosomes.
MARTIN (Host): Yeah. These are called telomeres, and normally, they get shorter with age. But what about in space?
SUSAN BAILEY (Principle Investigator): What we wanted to do was evaluate telomere length in both of the twins before and after so that we could see, you know, where they started and then where they ended.
MARTIN: Susan Bailey was one of the scientists who answered this question. She expected the stresses of space to shorten telomeres quicker.
BAILEY: And, in fact, we saw exactly the opposite thing - that during spaceflight, he had many more long telomeres than he did before he went up. So that really couldn't have been more of a surprise to us.
See also Radiation Biologist Dr. Susan Bailey Studies the Cellular Clocks of Astronaut Twins
Question: Why did investigators initially believe that Scott Kelley's year in space would accelerate the rate of telomere loss, relative to his baseline rate and the rate of his identical twin brother on the ground? What would be the postulated mechanisms?
molecular-biology radiation telomere
asked yesterday
uhohuhoh
1,6561339
$endgroup$
$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday
add a comment |
$begingroup$
The NPR News article and podcast Scientists Share Results From NASA's Twins Study says:
SCOTT KELLY (NASA Astronaut): You know, the symptomatic stuff is fine. I don't have any long-term negative feelings, physically, from being in space. Now, there's the things you can't feel. And hopefully, I will never learn that those are a problem.
GREENE (Host): Those things you can't feel - well, it turns out they are as small as the protective structures at the ends of his chromosomes.
MARTIN (Host): Yeah. These are called telomeres, and normally, they get shorter with age. But what about in space?
SUSAN BAILEY (Principle Investigator): What we wanted to do was evaluate telomere length in both of the twins before and after so that we could see, you know, where they started and then where they ended.
MARTIN: Susan Bailey was one of the scientists who answered this question. She expected the stresses of space to shorten telomeres quicker.
BAILEY: And, in fact, we saw exactly the opposite thing - that during spaceflight, he had many more long telomeres than he did before he went up. So that really couldn't have been more of a surprise to us.
See also Radiation Biologist Dr. Susan Bailey Studies the Cellular Clocks of Astronaut Twins
Question: Why did investigators initially believe that Scott Kelley's year in space would accelerate the rate of telomere loss, relative to his baseline rate and the rate of his identical twin brother on the ground? What would be the postulated mechanisms?
molecular-biology radiation telomere
asked yesterday
uhohuhoh
1,6561339
$endgroup$
The NPR News article and podcast Scientists Share Results From NASA's Twins Study says:
SCOTT KELLY (NASA Astronaut): You know, the symptomatic stuff is fine. I don't have any long-term negative feelings, physically, from being in space. Now, there's the things you can't feel. And hopefully, I will never learn that those are a problem.
GREENE (Host): Those things you can't feel - well, it turns out they are as small as the protective structures at the ends of his chromosomes.
MARTIN (Host): Yeah. These are called telomeres, and normally, they get shorter with age. But what about in space?
SUSAN BAILEY (Principle Investigator): What we wanted to do was evaluate telomere length in both of the twins before and after so that we could see, you know, where they started and then where they ended.
MARTIN: Susan Bailey was one of the scientists who answered this question. She expected the stresses of space to shorten telomeres quicker.
BAILEY: And, in fact, we saw exactly the opposite thing - that during spaceflight, he had many more long telomeres than he did before he went up. So that really couldn't have been more of a surprise to us.
See also Radiation Biologist Dr. Susan Bailey Studies the Cellular Clocks of Astronaut Twins
Question: Why did investigators initially believe that Scott Kelley's year in space would accelerate the rate of telomere loss, relative to his baseline rate and the rate of his identical twin brother on the ground? What would be the postulated mechanisms?
molecular-biology radiation telomere
molecular-biology radiation telomere
asked yesterday
uhohuhoh
1,6561339
asked yesterday
uhohuhoh
1,6561339
edited yesterday
uhoh
asked yesterday
uhohuhoh
1,6561339
asked yesterday
uhohuhoh
1,6561339
asked yesterday
uhohuhoh
1,6561339
1,6561339
$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday
add a comment |
$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday
$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday
$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday
add a comment |
1 Answer
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Dr. Bailey wrote a short piece that hints at the factors behind her initial expectations:
Telomeres are the ends of chromosomes that protect them from damage and from “fraying” – much like the end of a shoestring. Telomeres are critical for maintaining chromosome and genome stability. However, telomeres naturally shorten as our cells divide, and so also as we age. The rate at which telomeres shorten over time is influenced by many factors, including oxidative stress and inflammation, nutrition, physical activity, psychological stresses and environmental exposures like air pollution, UV rays and ionizing radiation. Thus, telomere length reflects an individual’s genetics, experiences and exposures, and so are informative indicators of general health and aging...
Our study proposed that the unique stresses and out-of-this-world exposures the astronauts experience during spaceflight – things like isolation, microgravity, high carbon dioxide levels and galactic cosmic rays – would accelerate telomere shortening and aging. To test this, we evaluated telomere length in blood samples received from both twins before, during and after the one year mission.
answered yesterday
Alex ReynoldsAlex Reynolds
61669
$endgroup$
add a comment |
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$begingroup$
Dr. Bailey wrote a short piece that hints at the factors behind her initial expectations:
Telomeres are the ends of chromosomes that protect them from damage and from “fraying” – much like the end of a shoestring. Telomeres are critical for maintaining chromosome and genome stability. However, telomeres naturally shorten as our cells divide, and so also as we age. The rate at which telomeres shorten over time is influenced by many factors, including oxidative stress and inflammation, nutrition, physical activity, psychological stresses and environmental exposures like air pollution, UV rays and ionizing radiation. Thus, telomere length reflects an individual’s genetics, experiences and exposures, and so are informative indicators of general health and aging...
Our study proposed that the unique stresses and out-of-this-world exposures the astronauts experience during spaceflight – things like isolation, microgravity, high carbon dioxide levels and galactic cosmic rays – would accelerate telomere shortening and aging. To test this, we evaluated telomere length in blood samples received from both twins before, during and after the one year mission.
answered yesterday
Alex ReynoldsAlex Reynolds
61669
$endgroup$
add a comment |
$begingroup$
Dr. Bailey wrote a short piece that hints at the factors behind her initial expectations:
Telomeres are the ends of chromosomes that protect them from damage and from “fraying” – much like the end of a shoestring. Telomeres are critical for maintaining chromosome and genome stability. However, telomeres naturally shorten as our cells divide, and so also as we age. The rate at which telomeres shorten over time is influenced by many factors, including oxidative stress and inflammation, nutrition, physical activity, psychological stresses and environmental exposures like air pollution, UV rays and ionizing radiation. Thus, telomere length reflects an individual’s genetics, experiences and exposures, and so are informative indicators of general health and aging...
Our study proposed that the unique stresses and out-of-this-world exposures the astronauts experience during spaceflight – things like isolation, microgravity, high carbon dioxide levels and galactic cosmic rays – would accelerate telomere shortening and aging. To test this, we evaluated telomere length in blood samples received from both twins before, during and after the one year mission.
answered yesterday
Alex ReynoldsAlex Reynolds
61669
$endgroup$
add a comment |
$begingroup$
Dr. Bailey wrote a short piece that hints at the factors behind her initial expectations:
Telomeres are the ends of chromosomes that protect them from damage and from “fraying” – much like the end of a shoestring. Telomeres are critical for maintaining chromosome and genome stability. However, telomeres naturally shorten as our cells divide, and so also as we age. The rate at which telomeres shorten over time is influenced by many factors, including oxidative stress and inflammation, nutrition, physical activity, psychological stresses and environmental exposures like air pollution, UV rays and ionizing radiation. Thus, telomere length reflects an individual’s genetics, experiences and exposures, and so are informative indicators of general health and aging...
Our study proposed that the unique stresses and out-of-this-world exposures the astronauts experience during spaceflight – things like isolation, microgravity, high carbon dioxide levels and galactic cosmic rays – would accelerate telomere shortening and aging. To test this, we evaluated telomere length in blood samples received from both twins before, during and after the one year mission.
answered yesterday
Alex ReynoldsAlex Reynolds
61669
$endgroup$
Dr. Bailey wrote a short piece that hints at the factors behind her initial expectations:
Telomeres are the ends of chromosomes that protect them from damage and from “fraying” – much like the end of a shoestring. Telomeres are critical for maintaining chromosome and genome stability. However, telomeres naturally shorten as our cells divide, and so also as we age. The rate at which telomeres shorten over time is influenced by many factors, including oxidative stress and inflammation, nutrition, physical activity, psychological stresses and environmental exposures like air pollution, UV rays and ionizing radiation. Thus, telomere length reflects an individual’s genetics, experiences and exposures, and so are informative indicators of general health and aging...
Our study proposed that the unique stresses and out-of-this-world exposures the astronauts experience during spaceflight – things like isolation, microgravity, high carbon dioxide levels and galactic cosmic rays – would accelerate telomere shortening and aging. To test this, we evaluated telomere length in blood samples received from both twins before, during and after the one year mission.
answered yesterday
Alex ReynoldsAlex Reynolds
61669
answered yesterday
Alex ReynoldsAlex Reynolds
61669
answered yesterday
Alex ReynoldsAlex Reynolds
61669
answered yesterday
Alex ReynoldsAlex Reynolds
61669
61669
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$begingroup$
I've added the radiation tag since it is a known difference between spending a year in space versus on the ground, but I don't know if that will be part of the answer or not.
$endgroup$
– uhoh
yesterday